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With the success of mRNA vaccines during the COVID-19 pandemic and CAR T-cell therapies in clinical trials, there is growing opportunity for immunotherapies in the treatment of many types of cancers. Lentiviral vectors have proven effective at delivery of genetic material or gene editing technology for ex vivo processing, but the benefits and promise of Adeno-associated virus (AAV) and mRNA tools for in vivo immunotherapy have garnered recent interest. Here we describe complete synthetic solutions for immuno-oncology research programs using either mRNA-vaccines or virus-mediated cell and gene engineering. These solutions optimize workflows to minimize screening time while maximizing successful research results through: (1) Efficiency in lentiviral packaging with versatility in titer options for high-quality particles. (2) A highthroughput viral packaging process to enable rapid downstream screening. (3) Proprietary plasmid synthesis and preparation techniques to maintain ITR integrity through AAV packaging and improve gene delivery. (4) Rapid synthesis, in vitro transcription, and novel sequencing of mRNA constructs for complete characterization of critical components such as the polyA tail. The reported research demonstrates a streamlined approach that improves data quality through innovative synthesis and sequencing methodologies as compared to current standard practices.
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According to Jens Kürten, group senior director, Communication and Marketing, Gerresheimer, there are nine megatrends that will both characterize and influence the pharmaceutical packaging market. Whether the drug be injected intravenously or subcutaneously, at home or in a hospital setting, there are various needs that should be considered prior to choosing the 'best-fit' packaging, he adds. [...]packaging requirements for pharmaceuticals change over time as the lifecycle of the drug continues," Stöcker states. [...]customers request more eco-friendly options to reduce or avoid plastic. [...]it has been necessary to design the packaging for the vaccines with these specific requirements in mind to ensure the safety and efficacy of the therapeutic product are protected.
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This paper provides a critical overview of Design for Sustainability (DfS) and Design for Well-Being practices as, today, sustainability, human behavior, and well-being are inextricably linked. We present a case study in response to a pharmaceutical company brief about cosmetic self-production packaging. Since the research takes place during the first lockdown due to Covid-19, it depicts quite a complex and extensive desk phase and a limited field phase. The research is approached on two levels. First, is the intention to change the way we interact with the packaging. As a container of elements, packaging can be a resource on all levels, not only because we can recycle it but also because we can replant it. In this way, we would return part of what had been taken away to the environment while also improving the product's life cycle. Thus, packaging becomes "behavioral”, producing and stimulating conscious behavior and motivating end-users while also educating them about environmental norms. Second, the Critical Design method traces the connections between DfS and Design for Well-being by leveraging the two practices within product design, clarifying the role of the designer in this transdisciplinary integration. © 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.
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Vials are versatile;in addition to liquids, they can be used to package lyophilized and cryogenic products, as well as those in powder form. If there are stability issues, reformulation will be required;this decision will be influenced by the nature of the vaccine, preferred shipping methods, and the container options. In-house manufacture may require investment in new capacity for a dedicated line for mass production of a single product or a flexible filling operation that can handle multiple products and different size vials. Depending on the future global needs for vaccinations, prefilled syringes may gain a significant market share.
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PurposeThe purpose of this paper is to identify the radio frequency identification (RFID) strategic value attributes (RFIDSVAs) mechanism selections preferences and also integration of RFID tags with technology coordination tools (IRTWTCTs) alternatives ranking performance decisions in supply chain management (SCM). RFID-enabled techno-economic feasibility decisions are enhancing the SC visibility in apparel supply chains (ASCs). The RFIDSVAs mechanism selections have performed significant agility to strategic competitive advantages, namely, inventory visibility, multi-tags ownership transfer within trusted third party, etc.Design/methodology/approachFuzzy analytical hierarchy process (FAHP) and FAHP-fuzzy Technique for Order of Preference by Similarity to Ideal Solution (FTOPSIS) approaches have been used to evaluate the quantitative assessment of RFIDSVA mechanisms selection decision based on weight priority orders and IRTWTCTs alternatives selection in ASC networks. The comparison of FAHP and FAHP-FTOPSIS approaches to evaluate the integrated framework develop in RFIDSVAs mechanisms and IRTWTCTs alternatives selection decisions in Indian multi-tier ASC networks.FindingsThe result found that the FAHP-FTOPSIS approaches have used to prioritizing the RFIDSVA mechanism selection weights and also identify the IRTWTCTs alternatives ranking preferences order in apparel SCM. The comparison between the FAHP and FAHP-FTOPSIS approach to quantitative assessments from RFIDSVA mechanisms and IRTWTCTs alternatives selection decisions, which enable them SC agility potential across multi-tier visibility in ASC networks. ASC stakeholders can be benefited by techno-economic feasibility decisions, RFID-enabled shop floor activities, multi-tags ownerships transfer in SCs and knowledge-based cryptography tags/items separation in SCs.Research limitations/implicationsThe research work has considered only five RFIDSVA mechanisms and also three integration of RFIDTWTCTs alternatives in multi-tier ASC. The strategic competitive advantages are achieved by RFID-enabled break-even tags price decisions and also techno-economic feasibility decision by contractual design multi-tier SC stakeholder's involvements.Practical implicationsThe pilot project study explores that the quantitative assessment decision has based on RFID-enable techno-economic feasibility in ASCs. Stakeholders can be benefited by inventory control of the financial losses, reducing the inventory inaccuracies and multi-tags ownership transfer within trusted third-party traceability in ASC networks.Originality/valueThis study explores the RFID-enabled apparel SC process and activities visibility (natural fibre's fibre producer, fibre dyeing producer, yarn spinning producer, knitting and finishing producer).
ABSTRACT
[...]SCHOTT, which operates a global validated production network with 20 plants and more than 600 production lines for pharma glass and packaging, already has delivered millions of glass vials to SARS-CoV-2 programmes including supplying three out of every four COVID-19 vaccine projects undergoing Phase I, II, and III testing (3). Since we produce the pharmaceutical glass tubing for the packaging ourselves, we are also able to adjust the capacities for glass production in advance, which also benefits packaging manufacturers who do not have their own glass production facilities." "Since our sites are already validated by the authorities and by major pharma companies, our expansion is happening at a very fast pace," reports Stöcker. Per the agreement ... with BARDA [Biomedical Advanced Research and Development Authority, part of the US Department of Health and Human Services' Office of the Assistant Secretary for Preparedness and Response], Corning will provide priority access to designated BARDA vaccine and drug development partners."
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Single-use plastic (SUP) products are designed to be used only once or for a short time before being discarded. This research focused on personal protective equipment (PPE) made of SUP-based products (face masks, gloves, etc.) and SUP packaging during the COVID-19 era. One of the most obvious effects of the pandemic has been the increase in the use of PPE not only by healthcare professionals but also by the general public. As part of the fight against the pandemic, quarantines were started in many countries;people had to work from home, and shops were closed. Online shopping became more common. The increase in e-commerce also increased the use of SUP packaging. Here, we present an estimation of the number of daily single-use face masks and the amount of medical waste, considering the current COVID-19 cases and population. As a result of our calculations, we show that while the daily amount of medical waste is greatest in the European region, the number of single-use face masks used each day is highest in Asia. These results are associated with the number of COVID-19 cases and population data in the regions. Medical waste and number of patients were directly proportional, as were population and face mask waste. We are faced with plastic pollution that is becoming more difficult to control each day. In the current circumstances, within the scope of combating the possible plastic pandemic, we should prevent the shift of beneficial plastic from a preservative to a pollutant by prioritizing individual, societal, and institutional reforms to minimize plastic pollution. © 2023 John Wiley & Sons Ltd.
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The people who work at companies that manufacture chromatography instruments and consumables are often well positioned to be aware of developments, needs, and trends that not everyone else sees, because they serve customers in a range of areas of focus and with diverse demands-such as academic researchers investigating fundamental aspects of separation science techniques, industrial analysts solving problems that they may not be allowed to talk about at conferences, or chemists working in government laboratories in areas like environmental research. Inaccurate data can be generated from variable, glass vial surface chemistries, which can lead to investigations or flawed decisions can be made from these results. The Reduced Surface Activity (RSA(tm)) Glass Technology was developed to address these issues, and to provide chemists with sample containers for LC-MS, MS, HPLC, GC, and CE that deliver reliable, consistent results by not adsorbing basic analytes, or adding metals to, or changing the pH of the diluent. The stringent RSA manufacturing processes are continued through to final contaminate-free packaging and quality control, where they are tested for adsorption, metal content, and residual materials.
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SARS-CoV-2 is still spreading globally. Studies have reported the stability of SARS-CoV-2 in aerosols and on surfaces under different conditions. However, studies on the stability of SARS-CoV-2 and viral nucleic acids on common food and packaging material surfaces are insufficient. The study evaluated the stability of SARS-CoV-2 using TCID50 assays and the persistence of SARS-CoV-2 nucleic acids using droplet digital polymerase chain reaction on various food and packaging material surfaces. Viral nucleic acids were stable on food and material surfaces under different conditions. The viability of SARS-CoV-2 varied among different surfaces. SARS-CoV-2 was inactivated on most food and packaging material surfaces within 1 day at room temperature but was more stable at lower temperatures. Viruses survived for at least 1 week on pork and plastic at 4°C, while no viable viruses were detected on hairtail, orange, or carton after 3 days. There were viable viruses and a slight titer decrease after 8 weeks on pork and plastic, but titers decreased rapidly on hairtail and carton at -20°C. These results highlight the need for targeted preventive and disinfection measures based on different types of foods, packaging materials, and environmental conditions, particularly in the cold-chain food trade, to combat the ongoing pandemic.
Subject(s)
COVID-19 , Nucleic Acids , Humans , SARS-CoV-2/genetics , Biological Assay , PlasticsABSTRACT
Dust or condensed water present in harsh outdoor or high-humidity human breath samples are one of the key sources that cause false detection in Micro Electro-Mechanical System (MEMS) gas sensors. This paper proposes a novel packaging mechanism for MEMS gas sensors that utilizes a self-anchoring mechanism to embed a hydrophobic polytetrafluoroethylene (PTFE) filter into the upper cover of the gas sensor packaging. This approach is distinct from the current method of external pasting. The proposed packaging mechanism is successfully demonstrated in this study. The test results indicate that the innovative packaging with the PTFE filter reduced the average response value of the sensor to the humidity range of 75~95% RH by 60.6% compared to the packaging without the PTFE filter. Additionally, the packaging passed the High-Accelerated Temperature and Humidity Stress (HAST) reliability test. With a similar sensing mechanism, the proposed packaging embedded with a PTFE filter can be further employed for the application of exhalation-related, such as coronavirus disease 2019 (COVID-19), breath screening.
Subject(s)
COVID-19 , Micro-Electrical-Mechanical Systems , Humans , Micro-Electrical-Mechanical Systems/methods , Reproducibility of Results , Humidity , PolytetrafluoroethyleneABSTRACT
The COVID-19 pandemic has been challenging for the hotel industry, with rooms being converted into quarantine centres and leading to an increase in waste volume and composition. With frequent lockdowns and stringent guidelines by governments on social distancing, 60% of hotels converted 10% of their rooms into quarantine facilities, which drastically changed the composition of hotel waste (JLL, 2020). This waste may lead to environmental degradation if handled inappropriately. The primary objective of this study is to identify, compare and highlight the challenges faced in waste management practices in two different circumstances, namely pre-COVID and during-COVID, in the hotel industry. Data were collected using a structured questionnaire put to hoteliers in selected hotels in India. A total of 61 responses were recorded out of 100 respondents. Descriptive analysis indicated new practices in hotel housekeeping such as use of single-use PPE kits, arrangement of separate zones for disposing of medical waste and digitalization of services. Another interesting finding of the research is the aggravation of single-use plastic in the form of disposable crockery, cutlery and packaging of PPE kits. Lastly, the study showed an increase in operational costs and highlighted innovative procedures in existing waste management disposal practices and suggested new practices that will be of great significance for dealing with similar episodes in the future.
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Products of the polymer industry, the lion's share of which is food packaging, create a significant threat to the en-vironment, which requires a search for the most effective and functional solutions to this problem. Every year, the production of polymer packaging is growing by an average of 10-12%, and last year, due to the worldwide spread of SARS-CoV-2 (COVID-19) and its strains, the increase was more than 20%. A solution to the environmental problem is possible using the main basic approaches: disposal and recycling of waste, which will give the pos-sibility of the "second life” to already used polymers;development and creation of new biodegradable materials capable of degrading completely under the influence of external factors into relatively safer substances. However, it should be noted that the first method has a number of significant drawbacks associated with the difficulty in controlling the amount of recycling processes carried out, which can potentially lead to an increase in migration processes from polymeric materials. The second way to solve the environmental problem of packaging disposal and recycling is the direction associated with the creation of polymeric materials with the replacement of part of the traditional commercial synthetic bases with organic and inorganic fillers in various concentrations. However, the most promising way to handle packaging waste, in our opinion, is the development of technologies aimed at creating fully biodegradable materials with a regulated service life, which, after their life cycle, are disposed of in a short time without harming the environment. This review is devoted to the analysis of the market of modern biodegradable materials and methods for obtaining degradable compositions that can become a significant alternative to traditional plastics. © Myalenko D. M., 2023.
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Coronavirus disease is a contagious respiratory ailment that has spread significantly around the world. Most cases of COVID-19 are spread from person to person by coming into contact with respiratory droplets that are released when an infected person coughs or sneezes. In this manuscript, we have highlighted the possible transmission of COVID-19 through food, water, air and paper. In the case of food, we have extensively covered the transmission of COVID-19 through meat, frozen foods, food packaging and food market along with the incidences worldwide. In the nextsection, we have highlighted the different components of air which are responsible for the transmission and also covered its relation with PM 2.5 incidence. The SARS-CoV-2 was isolated from sewage water/wastewater of various countries namely the United States, India, Australia, Netherlands and France signifying that wastewater can be a mode of virus transmission. The paper circulation by the infected COVID-19 patients can also be a virus conveyance route. It can be concluded that SARS-CoV-2 can therefore be transmitted indirectly through food via the workers involved in food packing or food marts.By following general safety precautions (wearing masks, using hand sanitisers, cleaning and disinfecting contact surfaces, and avoiding close contact), heating and using chemicals like ethanol (67-71%), sodium hypochlorite (0.1%) and hydrogen peroxide (0.5%) on environmental surfaces, along with vaccination, it is possible to reduce the spread of the SARS-CoV-2 virus.Copyright © 2023 The International Journal of Pharmaceutical Research and Allied Sciences (IJPRAS).
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The poly(vinyl alcohol) (PVA) and starch-based polymeric films with a ratio of 2:8 were prepared using solution casting followed by a solvent evaporation method. Four types of membranes with varied concentrations of grapefruit seed extract (GSE) i.e., 2.5-10 wt% was incorporated in the films. The prepared membranes were assessed for transparency test, mechanical properties, surface morphology, permeability test for O2, and antimicrobial properties. The PVA/starch-10% GSE loaded film showed excellent mechanical properties showing highest 1344 ± 0.7% elongation at break but poor optical transparency with 53.8% to 68.61%. The Scanning Electron Microscopic study reveals the good compatibility between the PVA, Starch, and GSE. The gas permeability test reveals that the prepared films have shown good resistance to the O2 permeability 0.0326-0.316 Barrer at 20 kg/cm2 feed pressure for the prepared membranes showing excellent performance. By adding the little amount of GSE into the PVA/starch blend membranes showed promising antimicrobial efficacy against MNV-1. For 4 h. incubation, PVA/starch blend membranes containing 2.5%, 5%, and 10% GSE caused MNV-1 reductions of 0.92, 1.89, and 2.27 log PFU/ml, respectively. Similarly, after 24 h, the 5% and 10% GSE membranes reduced MNV-1 titers by 1.90 and 3.26 log PFU/ml, respectively. Antimicrobial tests have shown excellent performance to resist microorganisms. The water uptake capacity of the membrane is found 72% for the PVA/starch pristine membrane and is reduced to 32% for the 10% GSE embedded membrane. Since the current pandemic situation due to COVID-19 occurred by SARSCOV2, the prepared GSE incorporated polymeric blend films are the rays of hope in the packaging of food stuff.
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The pandemic caused by SARS-CoV-2 has a huge impact on the global economy. SARS-CoV-2 could possibly and potentially be transmitted to humans through cold-chain foods and packaging (namely good-to-human), although it mainly depends on a human-to-human route. It is imperative to develop countermeasures to cope with the spread of viruses and fulfil effective surveillance of cold-chain foods and packaging. This review outlined SARS-CoV-2-related cold-chain food incidents and current methods for detecting SARS-CoV-2. Then the needs, challenges and practicable countermeasures for SARS-CoV-2 detection, specifically for cold-chain foods and packaging, were underlined. In fact, currently established detection methods for SARS-CoV-2 are mostly used for humans; thus, these may not be ideally applied to cold-chain foods directly. Therefore, it creates a need to develop novel methods and low-cost, automatic, mini-sized devices specifically for cold-chain foods and packaging. The review intended to draw people's attention to the possible spread of SARS-CoV-2 with cold-chain foods and proposed perspectives for futuristic cold-chain foods monitoring during the pandemic.
Subject(s)
COVID-19 , Humans , COVID-19/epidemiology , COVID-19/prevention & control , SARS-CoV-2ABSTRACT
The purpose of this research is to study the changes in the market structure of China's pulp and paper product imports. In particular, the import trade environment and market layout of Chinese pulp and paper products have changed under the international context of the coronavirus pandemic and the Sino-US trade dispute and the domestic policy context of zero imports of Chinese waste paper. This study attempts to fill the gap regarding the influencing factors of market structure, while contributing new ideas on China's trade in pulp and paper products. Based on pulp and paper product import and export trade data from 2005 to 2021, a trade gravity model was used to explore the changes in the share of China's trade partners for pulp and paper product imports and their influencing factors. The results indicated that the outbreak of COVID-19 led to a significant increase in China's imports of packaging paper products, bringing about an increase in Indonesia's status as a partner in China's pulp and paper product trade. The US-China trade dispute had an impact on pulp and paper product trade between the two countries, with China's tax countermeasures causing the US to lose its status as a trading partner in China for pulp and paper product imports. The center of gravity for paper product imports has moved from the US and Japan to Indonesia and Russia. The restrictions on waste paper imports have shifted the focus of China's paper raw material imports, with the US no longer being the main importer of China's paper raw materials. Specifically, the main importers of wood pulp are Brazil and Chile, while the main importers of waste paper pulp are Thailand and Malaysia. In the future, China needs to continuously strengthen dialogue with the United States to resolve trade disputes and create a favorable environment for trade in pulp and paper products. At the same time, China's paper enterprises should strengthen the expansion of the Southeast Asian market and reduce dependence on the US market, and China should continue to improve the waste paper recycling system and improve the utilization rate of domestic waste paper.
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Horticulture, with its different disciplines (Horticulture/Olericulture, Fruit-growing, Aromatic-Medicinal and Floriculture), has become more relevant, since the Covid-19 pandemic, with a greater appreciation of products from short chains. The objective was to evaluate the degree of knowledge, behavior and preferences of Latin American consumers, regarding the safety, quality and origin of local fruits and vegetables (F&H) produced and consumed within a radius of no more than 100 km, differentiated with the "Km 0” logo. An online survey was generated (GoogleForms): Study on the Latin American production and consumption of "Km 0" fruits and vegetables, within the framework of inter-institutional links (UNCPBA, UNMDP, UNSL, UCA and INTA CERBAS Area, from Argentina;UdelaR, Uruguay;UNAL and UniSalle, Colombia;BUAP, Mexico;UFRRJ, Brazil), from 03/09/2022 to 07/12/2022. The main topics were: Degree of knowledge of the F&H category "Km 0”;Perceived benefits;Predisposition to consume and acquire them;Degree of evaluation of the "Km 0” labelling;and dissemination campaigns;Places of purchase and changes since the pandemic;Valuation of having lists of local producers of F&H "Km 0”;Knowledge of the place of production of the F&H and assessment of the promotion of local productions;Knowledge of GAP;Acquired food and Assessment of the origin of F&H consumed. The surveys answered were 1127. Ignorance of the "Km 0” category was detected (60%), low consumption of F&H (17% consume 5 ≥ portions/day) although there is a high assessment of F&H in the diet (80%). The need for permanent training and dissemination, of the production and consumption of safe and quality F&H, in quantity and diversity, was evidenced. The pandemic was a turning point from which consumers became aware of the importance of the origin of the products consumed, preferring local F&H. © 2022, Asociacion Argentina de Horticultura - ASAHO. All rights reserved.